Amyotrophic lateral sclerosis (ALS)
| PAG Title | Amyotrophic lateral sclerosis (ALS) |
| PAG ID | WAG000207 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | "Drug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic system that projects from the ventral tegmental area (VTA) of the midbrain to the nucleus accumbens (c), and to other forebrain sites, is the major substrate of reward and reinforcement for both tural rewards and addictive drugs. Cocaine binds strongly to the dopamine-reuptake transporter, preventing the reuptake of dopamine into the nerve termil. Because of this blocking effect, dopamine remains at high concentrations in the sypse and continues to affect adjacent neurons, producing the characteristic cocaine """"high."""" Activated D1 receptor activates the PKA sigling pathway, and this pathway plays a critical role in mediating the behavioral responses to cocaine administration. Cocaine-induced neuroadaptations, including dopamine depletion, may underlie craving and hedonic dysregulation." |
| Species | Homo sapiens |
| nCoCo Score | 365 |
| Base PAG ID | WAG000207 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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